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KMID : 0358819870140020185
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1987 Volume.14 No. 2 p.185 ~ p.193
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THE EFFECT OF GENERAL ANESTHETICS ON THE SKIN FLAP SURVIVAL
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Lee Jong-Won
Choi Eung-Ok
Hong Sang-Pyo
Hwang Oh-Yeol
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Abstract
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Tissue nutrition is directly related to the functional status of the microcirculation because it is only in the terminal circulatory bed that exchanges between blood and cells are effective.
Anesthetic drugs are known to be associated with marked changes in microvascular functional activity and with important changes in the reactivity of microvessels to humoral stimulation.
The microcirculatory status of skin exposed to anesthetic drug is modified through direct, nervous or humoral mechanism.
Skin flap survival was observed on the experimentally made critical flap in the rat and the following results were obtained.
1. The survival rate in the ketamine and enflurane groups increased as compared to control group.
2. The survival rate in the ehter group was not different to control group.
3. The survival rate in the halothane group decreased significantly as compared to control group.
Harmful effect of halothane on skin flap decreases blood flow in venule rather than arteriole and the accumulation of its metabloites within skin flap inhibits oxygen consumption and glycolysis.
4. In conclusion, when the survival of flap was questionable, general naesthesia with ketamine and enflurane may be more preferable than that with halothane.
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KEYWORD
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